HIP14; ZDHHC17 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15465-1-AP

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Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Raji cells, human kidney tissue

Positive IHC detected in:
human testis

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
zinc finger, DHHC-type containing 17

Calculated molecular weight:
73 kDa

Observed molecular weight:
70kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ZDHHC17

Synonyms
ZDHHC17, HIP14, Palmitoyltransferase ZDHHC17, HIP 14, DHHC 17
Background

Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. ZDHHC17 gene encodes palmitoyl transferase huntingtin interacting protein (HIP14) which regulates palmitoylation and distribution of hungtingtin. The latter is implicated in the formation of inclusion bodies and enhanced neuronal toxicity. HIP14 was also shown to control neurotransmitter release.


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