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  • KD/KO Validated

SARA Polyclonal antibody

SARA Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IF, ELISA

Conjugate

Unconjugated

Cat no : 14821-1-AP

Synonyms

hSARA, Madh interacting protein, MADHIP, Novel serine protease, NSP, Receptor activation anchor, SARA, SMADIP, ZFYVE9



Product Information

14821-1-AP targets SARA in WB, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SARA fusion protein Ag6592
Full Name zinc finger, FYVE domain containing 9
Calculated Molecular Weight 1425 aa, 156 kDa
GenBank Accession NumberBC032680
Gene Symbol SARA
Gene ID (NCBI) 9372
RRIDAB_2219204
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ZFYVE9, also known as SARA (Smad anchor for receptor activation), is a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SARA functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. SARA plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. SARA is possibly associated with TGF-beta receptor internalization.

Protocols

Product Specific Protocols
WB protocol for SARA antibody 14821-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseIF

Mol Psychiatry

WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling.

Authors - Min Wang
  • KD Validated
humanWB

Oncotarget

TGFBR-IDH1-Cav1 axis promotes TGF-β signalling in cancer-associated fibroblast.

Authors - Xiaodan Hou
humanWB, IF

J Biol Chem

Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β1.

Authors - Runyan Constance E CE
mouseWB

Stem Cell Reports

Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool.

Authors - Xuanmao Jiao