beta-Catenin Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 17565-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
A431 cells, mouse brain tissue, NIH/3T3 cells, rat brain tissue, HeLa cells, MCF-7 cells, mouse liver tissue, HEK-293 cells

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
A431 cells, MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
catenin (cadherin-associated protein), beta 1, 88kDa

Calculated molecular weight:
781aa,86 kDa

Observed molecular weight:
92 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTNNB1

Synonyms
b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, PRO2286, β catenin, β-catenin
Background

β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin was originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)


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