phospho(403/404)-TDP43 Antibody 2 Publications

Mouse Monoclonal| Catalog number: 66079-1-Ig |CloneNo.: 6B11B12

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Freight/Packing

Con: 171 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
K-562 cells, fetal human brain tissue, human placenta tissue, Jurkat cells, RAW 264.7 cells

Recommended dilution:
WB : 1:1000-1:6000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
TAR DNA binding protein

Calculated molecular weight:
43 kDa

Observed molecular weight:
25 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TARDBP

Synonyms
ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
Background

Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 66079-1-Ig is a mouse monoclonal antibody recognizing TDP-43 only when phosphorylated at 403/404. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 20-30 kDa. Immunohistochemical analyses using this antibody only stain the insoluble inclusions in pathologic tissues without normal diffuse nuclear staining.


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