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Phospho-Akt (Tyr315) Antibody 11 Publications

Mouse Monoclonal| Catalog number: 60072-1-Ig |CloneNo.: 5C4D12

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Con: 112 μg/150 μl

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Tested Applications

Applications:
WB, IF, ELISA
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Species specificity:
human, mouse, rat
Recommended dilution:
Sample-dependent, check data in Validation tab

Product Information

Source:
Mouse
Purification method:
Protein A purification
Isotype:
IgG2b
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
Phospho Peptide
Full name:
v-akt murine thymoma viral oncogene homolog 1
Calculated molecular weight:
56 kDa
Observed molecular weight:
62 kDa
GenBank accession number:
NM_005163
Gene ID (NCBI):
207
Gene symbol
AKT1
Synonyms

Background

Protein kinase B (PKB/Akt) has been well established as an important signaling intermediate, and its deregulation has been implicated in the development of human cancer and diabetes(PMID:12176337). Akt, also known as protein kinase B (PKB), is a serine/threonine kinase activated downstream of class I phosphatidylinositol 3-kinase (PI3K) and various receptors. It has emerged as the key regulator for many signal transduction pathways, modulating multiple processes such as cell survival, proliferation, growth, angiogenesis, and glucose metabolism(PMID:16139227). Its deregulation has been implicated in the development of human cancer and diabetes(PMID:12176337).


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