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Phospho-Akt (Tyr315) Antibody 11 Publications

Mouse Monoclonal| Catalog number: 60072-1-Ig |CloneNo.: 5C4D12

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Con: 112 μg/150 μl

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Tested Applications

Applications:
WB, IF, ELISA
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Species specificity:
human, mouse, rat
Recommended dilution:

Protocols

Product-specific protocols

    Standard Protocols

    Product Information

    Source:
    Mouse
    Purification method:
    Protein A purification
    Isotype:
    IgG2b
    Storage:
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

    Immunogen Information

    Immunogen:
    Phospho Peptide
    Full name:
    v-akt murine thymoma viral oncogene homolog 1
    Calculated molecular weight:
    56 kDa
    Observed molecular weight:
    62 kDa
    GenBank accession number:
    NM_005163
    Gene ID (NCBI):
    207
    Gene symbol
    AKT1
    Synonyms

    Background

    Protein kinase B (PKB/Akt) has been well established as an important signaling intermediate, and its deregulation has been implicated in the development of human cancer and diabetes(PMID:12176337). Akt, also known as protein kinase B (PKB), is a serine/threonine kinase activated downstream of class I phosphatidylinositol 3-kinase (PI3K) and various receptors. It has emerged as the key regulator for many signal transduction pathways, modulating multiple processes such as cell survival, proliferation, growth, angiogenesis, and glucose metabolism(PMID:16139227). Its deregulation has been implicated in the development of human cancer and diabetes(PMID:12176337).


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