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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human Cystatin C

Activity

Typically ≤ 5 µM IC50

Species Reactivity

Human

Purity

>95%

Cat no : HZ-1211

Synonyms

Cystatin C Cystatin-C, CystatinC



Technical Specifications

GeneID 1471
Species Human
Expression HEK293
Activity Typically ≤ 5 µM IC50
Purity >95%
Molecular Mass 12 to 13 kDa, monomer, nonglycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1x PBS.

Product Description

Animal-free Recombinant Human Cystatin C (Cys-C) is expressed in human 293 cells as a monomer with an apparent molecular mass of 12 to 13 kDa. Native Cys-C in human urine is found in two different forms: one with pI 9.2 and the other with pI 7.8 by elimination of small basic peptides or amino acids from the N-terminal end of protein. Cystatin C has been studied for its role in predicting newonset or deteriorating cardiovascular disease. This cytokine is produced in a serum-free, chemically defined media.

Background

Cystatin C is a 13-kDa protein that is expressed globally in the body. In healthy individuals, glomerular filtration in the kidney maintains it at a safe level. When kidney function is impaired, Cystatin C levels rise quickly. This makes it an early and sensitive biomarker of renal dysfunction (PMID 24848523). A mutation in Cystatin C has been associated with amyloid angiopathy (PMID 11409420). Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.

Synonyms

Cystatin C Cystatin-C, CystatinC