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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human FGF-8b

Activity

Typically ≤ 10 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1103

Synonyms

AIGF, Androgen induced growth factor, FGF 8, FGF8, FGF-8b, Fibroblast growth factor 8, HBGF 8, KAL6



Technical Specifications

GeneID 2253
Species human
Expression HEK293
Activity Typically ≤ 10 ng/mL EC50
Purity >95%
Molecular Mass 30 to 45 kDa, monomer, glycosylated
Formulation 10 mM Tris-HCl pH 7.4 + 800 mM NaCl, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile water containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human FGF-8b is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 30 to 45 kDa. This wide molecular mass is due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications. The cytokine is greater than 95% pure.

Background

Fibroblast growth factor 8 (FGF8), also known as AIGF and HBGF-8, belongs to the FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion (PMID: 11276432; 15863033). FGF8 stimulates growth in an autocrine manner in normal individuals but mediates hormonal action during tumorigenesis (PMID 17512240). Defects in FGF8 cause Kallmann syndrome type 6 (KAL6) and idiopathic hypogonadotropic hypogonadism (IHH) (PMID 18596921).

Synonyms

AIGF, Androgen induced growth factor, FGF 8, FGF8, FGF-8b, Fibroblast growth factor 8, HBGF 8, KAL6

Publications

SpeciesTitle
pig

NMR Biomed

MRI study of cryoinjury infarction in pig hearts: i. Effects of intrapericardial delivery of bFGF/VEGF embedded in alginate beads.

Authors - YYang