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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human LEFTY-1

Activity

Typically ≤ 2.5 µg/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1109

Synonyms

LEFTB, LEFTY1, LEFTYB, Protein lefty 1, Protein lefty B



Technical Specifications

GeneID 10637
Species human
Expression HEK293
Activity Typically ≤ 2.5 µg/mL EC50
Purity >95%
Molecular Mass 38 kDa, monomer, glycosylated
Formulation 10 mM Tris-HCl pH 7.4 + 50 mM NaCl + 0.5% CHAPS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile water containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human LEFTY-1 is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media.

Background

LEFTY-1 is a member of the TGF-beta family of proteins that plays a role in left-right asymmetry determination of organ systems during development. LEFTY-1 regulates transforming growth factor, mitogen-activated protein kinase and other signaling pathways, and is considered to have a potential anti-inflammatory function (PMID: 29286065; 26316705; 10500184; 9708731)

Synonyms

LEFTB, LEFTY1, LEFTYB, Protein lefty 1, Protein lefty B

Publications

SpeciesTitle
human

Stem Cells Dev

Lefty Glycoproteins in Human Embryonic Stem Cells: Extracellular Delivery Route and Posttranslational Modification in Differentiation.

Authors - ZhilaKhalkhali-Ellis