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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human VEGF165 protein

Activity

Typically ≤ 5 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1038

Synonyms

L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGF165, VEGFA, VPF



Technical Specifications

GeneID 7422
Species human
Expression HEK293
Activity Typically ≤ 5 ng/mL EC50
Purity >95%
Molecular Mass 45 kDa, homodimer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant serum albumin (HSA).

Background

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulphide-linked homodimer (PMID 10838264; 11329058). This growth factor induces proliferation and migration of vascular endothelial cells and is essential for physiological and pathological angiogenesis. Misregulations of this gene in mice result in abnormal embryonic blood vessel formation.

Synonyms

L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGF165, VEGFA, VPF

Publications

SpeciesTitle
human

J Exp Clin Cancer Res

Receptor tyrosine kinase inhibitor Sunitinib and integrin antagonist peptide HM-3 show similar lipid raft dependent biphasic regulation of tumor angiogenesis and metastasis.

Authors - Jialiang Hu
human

J Biosci Bioeng

Construction of 3D cardiac tissue with synchronous powerful beating using human cardiomyocytes from human iPS cells prepared by a convenient differentiation method.

Authors - Yumi Sasano
human

Oxid Med Cell Longev

Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.

Authors - Wenqing Bu
human

Cell Mol Biol Lett

ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model.

Authors - Yasuhiro Yoshida
human

Int J Neurosci

Vascular endothelial growth factor alleviates mitochondrial dysfunction and suppression of mitochondrial biogenesis in models of Alzheimer's disease.

Authors - Xiangtian Liu
human

Tissue Eng Part C Methods

Supersensitive Layer-by-Layer 3D Cardiac Tissues Fabricated on a Collagen Culture Vessel Using Human-Induced Pluripotent Stem Cells.

Authors - Yoshinari Tsukamoto