C1QA Polyklonaler Antikörper

C1QA Polyklonal Antikörper für WB, IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, ELISA

Konjugation

Unkonjugiert

Publikationen(15)

Kat-Nr. : 11602-1-AP

Synonyme

Complement C1q A chain



Geprüfte Anwendungen

Erfolgreiche Detektion in WBhuman plasma, humanes Kolongewebe, humanes Herzgewebe, humanes Lebergewebe, humanes Lungengewebe, humanes Milzgewebe
Erfolgreiche Detektion in IF/ICCHepG2-Zellen

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:1000-1:8000
Immunfluoreszenz (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

11602-1-AP bindet in WB, IF/ICC, ELISA C1QA und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen C1QA fusion protein Ag2141
Vollständiger Name complement component 1, q subcomponent, A chain
Berechnetes Molekulargewicht 245 aa, 26 kDa
Beobachtetes Molekulargewicht 26-30 kDa
GenBank-ZugangsnummerBC030153
Gene symbol C1QA
Gene ID (NCBI) 712
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The first component of complement, C1, is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. This antibody is raised against C1qA which is the A-chain polypeptide of human complement subcomponent C1q.

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
WB protocol for C1QA antibody 11602-1-APProtokoll herunterladen
IF protocol for C1QA antibody 11602-1-APProtokoll herunterladen
STANDARD-PROTOKOLLE
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
WB

Brain Behav Immun

PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice

Authors - Qian Zhao
WB

Neuron

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

Authors - Maud Gratuze
WB

Cell Mol Life Sci

Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson's disease

Authors - Wenlong Zhang
WB

J Neurosci

Immune quiescence of the brain is set by astroglial connexin 43.

Authors - Anne-Cécile Boulay
WB

Life Sci

Cognitive impairment in Alzheimer's disease FAD4T mouse model: Synaptic loss facilitated by activated microglia via C1qA

Authors - Cui Zhang
humanWB,IF

CNS Neurosci Ther

STING Driving Synaptic Phagocytosis of Hippocampal Microglia/Macrophages Contributes to Cognitive Impairment in Sepsis-Associated Encephalopathy in Mice

Authors - Xin Lv