C1QA Polyklonaler Antikörper
C1QA Polyklonal Antikörper für WB, IF/ICC, ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
WB, IF/ICC, ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 11602-1-AP
Synonyme
Geprüfte Anwendungen
| Erfolgreiche Detektion in WB | human plasma, humanes Kolongewebe, humanes Herzgewebe, humanes Lebergewebe, humanes Lungengewebe, humanes Milzgewebe |
| Erfolgreiche Detektion in IF/ICC | HepG2-Zellen |
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:8000 |
| Immunfluoreszenz (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| WB | See 13 publications below |
| IF | See 5 publications below |
Produktinformation
11602-1-AP bindet in WB, IF/ICC, ELISA C1QA und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| In Publikationen genannte Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | C1QA fusion protein Ag2141 |
| Vollständiger Name | complement component 1, q subcomponent, A chain |
| Berechnetes Molekulargewicht | 245 aa, 26 kDa |
| Beobachtetes Molekulargewicht | 26-30 kDa |
| GenBank-Zugangsnummer | BC030153 |
| Gene symbol | C1QA |
| Gene ID (NCBI) | 712 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS with 0.02% sodium azide and 50% glycerol |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
The first component of complement, C1, is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. This antibody is raised against C1qA which is the A-chain polypeptide of human complement subcomponent C1q.
Protokolle
| PRODUKTSPEZIFISCHE PROTOKOLLE | |
|---|---|
| WB protocol for C1QA antibody 11602-1-AP | Protokoll herunterladen |
| IF protocol for C1QA antibody 11602-1-AP | Protokoll herunterladen |
| STANDARD-PROTOKOLLE | |
|---|---|
| Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |
Publikationen
| Species | Application | Title |
|---|---|---|
Brain Behav Immun PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice | ||
Neuron TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4 | ||
Cell Mol Life Sci Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson's disease | ||
Life Sci Cognitive impairment in Alzheimer's disease FAD4T mouse model: Synaptic loss facilitated by activated microglia via C1qA | ||
CNS Neurosci Ther STING Driving Synaptic Phagocytosis of Hippocampal Microglia/Macrophages Contributes to Cognitive Impairment in Sepsis-Associated Encephalopathy in Mice |







