CCL18/MIP-4 Polyklonaler Antikörper

CCL18/MIP-4 Polyklonal Antikörper für IHC,ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

4

Kat-Nr. : 22303-1-AP

Synonyme

AMAC 1, AMAC1, C C motif chemokine 18, CC chemokine PARC, CCL18, CKb7, DC CK1, DCCK1, Dendritic cell chemokine 1, MIP 4, MIP4, PARC, SCYA18, Small inducible cytokine A18

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Galerie der Validierungsdaten

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  IHC staining of human heart using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:200 (under 10x lens).

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  IHC staining of human heart using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:200 (under 40x lens).

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  IHC staining of human tonsillitis using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human tonsillitis using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human heart using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human heart using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human pancreas using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human pancreas using 22303-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 22303-1-AP (CCL18/MIP-4 antibody at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Herzgewebe, humanes Pankreasgewebe, humanes Tonsillitisgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• IHC: See 3 publications below
• IF: See 1 publications below

Produktinformation

22303-1-AP bindet in IHC, IF, ELISA CCL18/MIP-4 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
• Berechnetes Molekulargewicht: 10 kDa
• GenBank-Zugangsnummer: NM_002988
• Gene symbol: CCL18
• Gene ID (NCBI): 6362
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CCL18 is a small cytokine belonging to the CC chemokine family. The effector functions that CCL18 exerts on the immune system is mainly on the adaptive immune system, while being produced and secreted mainly by innate immune system. Although the functions of CCL18 have been well studied in vitro, physiological effects of CCL18 in vivo have been difficult to characterize because there is no murine analog of CCL18. Only recently has the receptor for CCL18 been identified, and further characterization of CCL18 interactions with its receptor will lead to better understanding of the physiological role of CCL18 in humans.

Publikationen

Species	Application	Title
human	IHC	ACS Biomater Sci Eng; Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.; Authors - Binghui Liu
human	IHC	Front Immunol; Novel macrophage-related gene prognostic index for glioblastoma associated with M2 macrophages and T cell dysfunction; Authors - Hang Ji
human	IHC	J Cell Physiol; Surgical trauma-induced CCL18 promotes recruitment of regulatory T cells and colon cancer progression.; Authors - Zhirong Sun
human	IF	Nat Commun; Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis; Authors - Shu Zhang