CCR2b-specific Polyklonaler Antikörper
CCR2b-specific Polyklonal Antikörper für IHC, ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus
Anwendung
WB, IHC, IF, ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 16154-1-AP
Synonyme
Geprüfte Anwendungen
| Erfolgreiche Detektion in IHC | humanes Leberkarzinomgewebe, Mausmilzgewebe Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen. |
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| Immunhistochemie (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| WB | See 1 publications below |
| IHC | See 1 publications below |
| IF | See 2 publications below |
Produktinformation
16154-1-AP bindet in WB, IHC, IF, ELISA CCR2b-specific und zeigt Reaktivität mit human, Maus
| Getestete Reaktivität | human, Maus |
| In Publikationen genannte Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | Peptid |
| Vollständiger Name | chemokine (C-C motif) receptor 2 |
| Berechnetes Molekulargewicht | 41 kDa |
| GenBank-Zugangsnummer | NM_000648 |
| Gene symbol | CCR2 |
| Gene ID (NCBI) | 729230 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS with 0.02% sodium azide and 50% glycerol |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
CCR2 encodes a receptor for MCP1, functioning in inflammatory processes, tumor infiltration, and monocyte invasion of artery walls in atherosclerosis. There are two isoforms of CCR2, CCR2A and CCR2B. CCR2 isoforms were expressed by different cell subsets in both normal and IIM muscle. CCR2A was expressed in vessel walls and by some mononuclear cells, especially in cells involved in partial invasion in PM and IBM. CCR2B expression was observed in all satellite cells, in the muscular domain of neuromuscular junctions, and in some regenerative fibers of IIM, but not in inflammatory exudates. The sequences of the two isoforms are different from 314-374 aa. This antibody 16154-1-AP is raised against the peptide of 344-360 amino acids of CCR2b. It is specific to CCR2b.
Protokolle
| PRODUKTSPEZIFISCHE PROTOKOLLE | |
|---|---|
| IHC protocol for CCR2b-specific antibody 16154-1-AP | Protokoll herunterladenl |
| STANDARD-PROTOKOLLE | |
|---|---|
| Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |
Publikationen
| Species | Application | Title |
|---|---|---|
Cell Rep Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium | ||
Int J Mol Sci Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2) | ||
Cancer Med Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study |
Rezensionen
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
FH Larissa (Verified Customer) (04-14-2025) | We've used the CCR2b-specific Rabbit Polyclonal Antibody for both Western blot and immunohistochemistry with great results. Overall, a reliable and high-quality antibody that performs well in multiple applications.
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