ERCC6/CSB Polyklonaler Antikörper

ERCC6/CSB Polyklonal Antikörper für WB,ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB,ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20548-1-AP

Synonyme

ARMD5, ATP dependent helicase ERCC6, CKN2, Cockayne syndrome protein CSB, COFS, COFS1, CSB, ERCC6, RAD26

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Galerie der Validierungsdaten

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  WB analysis of mouse brain using 20548-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 20548-1-AP (ERCC6/CSB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse brain using 20548-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 20548-1-AP (ERCC6/CSB antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Maushirngewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

20548-1-AP bindet in WB,ELISA ERCC6/CSB und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
• Berechnetes Molekulargewicht: 168 kDa
• Beobachtetes Molekulargewicht: 150 kDa
• GenBank-Zugangsnummer: NM_000124
• Gene symbol: ERCC6
• Gene ID (NCBI): 2074
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ERCC6, also named as CSB, belongs to the SNF2/RAD54 helicase family. It is involved in the preferential repair of active genes. It is presumed DNA or RNA unwinding function. ERCC6 corrects the UV survival and RNA synthesis after UV exposure of Cockayne syndrome complementation group B. Defects in ERCC6 are the cause of Cockayne syndrome type B (CSB) , cerebro-oculo-facio-skeletal syndrome type 1 (COFS1), De Sanctis-Cacchione syndrome (DSC), and UV-sensitive syndrome (UVS). Genetic variation in ERCC6 is associated with susceptibility to age-related macular degeneration type 5 (ARMD5). The antibody is specific to ERCC6.