FUNDC1 Polyklonaler Antikörper

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• KD/KO Validated

FUNDC1 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte und mehr (2)

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen(8)

Kat-Nr. : 28519-1-AP

Synonyme

FUN14 domain containing 1, FUN14 domain-containing protein 1, FUNDC 1

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  WB analysis using 28519-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 28519-1-AP (FUNDC1 antibody) at dilution of 1:40000 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 28519-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 28519-1-AP (FUNDC1 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: RAW 264.7-Zellen, C6-Zellen, Maushirngewebe, Mauslebergewebe, Rattenhirngewebe, Rattenlebergewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:5000-1:20000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 8 publications below

Produktinformation

28519-1-AP bindet in WB, ELISA FUNDC1 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Affe, Maus, Ratte, Ziege
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FUNDC1 fusion protein Ag29358
• Vollständiger Name: FUN14 domain containing 1
• Berechnetes Molekulargewicht: 155 aa, 17 kDa
• Beobachtetes Molekulargewicht: 17 kDa
• GenBank-Zugangsnummer: BC042813
• Gene symbol: FUNDC1
• Gene ID (NCBI): 139341
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FUNDC1 is a novel mitochondrial-associated membrane (MAM) protein, enriched at the MAM by interacting with the ER resident protein CANX (calnexin) under hypoxia. As mitophagy proceeds, it dissociates from CANX and preferably recruits DNM1L/DRP1 to drive mitochondrial fission in response to hypoxic stress.

Publikationen

Species	Application	Title
mouse	WB	Clin Sci (Lond); Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning; Authors - Limin Shi ; KD Validated
goat	WB	FASEB J; Zearalenone modulates the function of goat endometrial cells via the mitochondrial quality control system; Authors - Guomin Zhang
mouse	WB	Mech Ageing Dev; Deletion of Stimulator of Interferons Genes Aggravated Cardiac Dysfunction in Physiological Aged Mice; Authors - Diansa Gao
human	WB	Commun Biol; Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1; Authors - Shuo Wang
human	WB	J Exp Clin Cancer Res; Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling; Authors - Wei Chen
monkey	WB	PLoS Pathog; Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation; Authors - Zhe Sun