IGFBP6 Monoklonaler Antikörper
IGFBP6 Monoklonal Antikörper für
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human
Anwendung
Konjugation
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1D12B3
Kat-Nr. : CL488-67567
Synonyme
Geprüfte Anwendungen
Produktinformation
CL488-67567 bindet in IGFBP6 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG2b |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | IGFBP6 fusion protein Ag30050 |
| Vollständiger Name | insulin-like growth factor binding protein 6 |
| Berechnetes Molekulargewicht | 25 kDa |
| Beobachtetes Molekulargewicht | 30-33 kDa |
| GenBank-Zugangsnummer | BC011708 |
| Gene symbol | IGFBP6 |
| Gene ID (NCBI) | 3489 |
| Konjugation | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Insulin-like growth factor (IGF) binding protein (IGFBP6), a 240 amino acid protein, contains an IGFBP N-terminal domain and a thyroglobulin type-1 domain. It modulates the activity of IGF and shows independent effects of IGF, such as growth inhibition and apoptosis. It can decrease the proliferation and survival of cancer cells such as lung cancer cells and naso-pharyngeal cancer cells. IGFBP-6 is distinctive for its 50-fold higher binding affinity for IGF-II over IGF-I and this specificity makes it an attractive potential therapeutic candidate for IGF-II-dependent pediatric malignancies such as rhabdomyosarcoma (RMS). In addition, it was found that IGFBP6 can promote the migration of RMS cells in an IGF-independent manner, and MAPK pathways were involved in this process. Further study reported that IGFBP6 is one of most highly expressed proteins in varicose vein tissues and is involved in the proliferation of vascular smooth muscle cells (VSMCs), which may provide insights into the underlying pathogenesis of varicose vein.
