IL-5 Rekombinanter Antikörper

IL-5 Rekombinant Antikörper für FC (Intra)

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC (Intra)

Konjugation

Unkonjugiert

CloneNo.

240915D12

Kat-Nr. : 98178-1-RR

Synonyme

IL5, Interleukin-5, Interleukin 5, IL 5, B-cell differentiation factor I



Geprüfte Anwendungen

Erfolgreiche Detektion in FC (Intra)PMA, Ionomycin and Brefeldin A treated human PBMCs

Empfohlene Verdünnung

AnwendungVerdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98178-1-RR bindet in FC (Intra) IL-5 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name interleukin 5 (colony-stimulating factor, eosinophil)
Berechnetes Molekulargewicht 134 aa, 15 kDa
GenBank-ZugangsnummerBC066282
Gene symbol IL5
Gene ID (NCBI) 3567
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS with 0.09% sodium azide
LagerungsbedingungenStore at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity. (PMID: 21986312, 22174445, 19819937, 16895557)

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
FC protocol for IL-5 antibody 98178-1-RRDownload protocol
STANDARD-PROTOKOLLE
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