IL-5 Rekombinanter Antikörper
IL-5 Rekombinant Antikörper für FC (Intra)
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
FC (Intra)
Konjugation
Unkonjugiert
CloneNo.
240915D12
Kat-Nr. : 98178-1-RR
Synonyme
Geprüfte Anwendungen
Erfolgreiche Detektion in FC (Intra) | PMA, Ionomycin and Brefeldin A treated human PBMCs |
Empfohlene Verdünnung
Anwendung | Verdünnung |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, check data in validation data gallery |
Produktinformation
98178-1-RR bindet in FC (Intra) IL-5 und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | Rekombinantes Protein |
Vollständiger Name | interleukin 5 (colony-stimulating factor, eosinophil) |
Berechnetes Molekulargewicht | 134 aa, 15 kDa |
GenBank-Zugangsnummer | BC066282 |
Gene symbol | IL5 |
Gene ID (NCBI) | 3567 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein A purfication |
Lagerungspuffer | PBS with 0.09% sodium azide |
Lagerungsbedingungen | Store at 2 - 8°C. Stable for one year after shipment. |
Hintergrundinformationen
IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity. (PMID: 21986312, 22174445, 19819937, 16895557)
Protokolle
PRODUKTSPEZIFISCHE PROTOKOLLE | |
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FC protocol for IL-5 antibody 98178-1-RR | Download protocol |
STANDARD-PROTOKOLLE | |
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Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |