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MTMR2 Monoklonaler Antikörper
MTMR2 Monoklonal Antikörper für
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human
Anwendung
Konjugation
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1B11B7
Kat-Nr. : CL488-67312
Synonyme
Geprüfte Anwendungen
Produktinformation
CL488-67312 bindet in MTMR2 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG2b |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | MTMR2 fusion protein Ag28413 |
| Vollständiger Name | myotubularin related protein 2 |
| Berechnetes Molekulargewicht | 73 kDa |
| Beobachtetes Molekulargewicht | 66-73 kDa |
| GenBank-Zugangsnummer | BC052990 |
| Gene symbol | MTMR2 |
| Gene ID (NCBI) | 8898 |
| Konjugation | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.
