NK1.1 (CD161) Monoklonaler Antikörper

NK1.1 (CD161) Monoklonal Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

FITC Fluorescent Dye

CloneNo.

PK136

Kat-Nr. : FITC-65138

Synonyme

CD161, Klrb1a, Ly55a, NK1.1, NK1.1 (CD161), NKR P1A, Nkrp1 a, NKRP12, Nkrp1a

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Galerie der Validierungsdaten

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  FC experiment of mouse splenocytes using FITC-65138

  1X10^6 mouse splenocytes were surface stained with APC Anti-Mouse CD49b (DX5) (APC-65065, Clone: DX5) and FITC Mouse IgG2a isotype control antibody (left) or 0.5 ug FITC Anti-Mouse NK1.1 (CD161) (FITC-65138, Clone: PK136) (right). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Splenozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

FITC-65138 bindet in FC NK1.1 (CD161) und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: NK-1+-Zellen aus Mausmilz und -knochenmark
• Vollständiger Name: killer cell lectin-like receptor subfamily B member 1A
• GenBank-Zugangsnummer: BC120707
• Gene symbol: Klrb1a
• Gene ID (NCBI): 17057
• Konjugation: FITC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 494 nm / 520 nm
• Form: Liquid
• Reinigungsmethode: Affinitätsreinigung
• Lagerungspuffer: Phosphatbasierter Puffer mit 0,09% Natriumazid und 0,1% Gelatine, pH 7,2.
• Lagerungsbedingungen: Bei 2-8°C lagern. Vor Licht schützen. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).