Progesterone Receptor Monoklonaler Antikörper

Progesterone Receptor Monoklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

IHC, ELISA

Konjugation

Unkonjugiert

Publikationen(2)

CloneNo.

3D1D12

Kat-Nr. : 66300-1-Ig

Synonyme

PGR, 3D1D12, NR3C3, PR, PRGR

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  IHC staining of human breast cancer using 66300-1-Ig

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (Progesterone Receptor antibody) at dilution of 1:9900 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human breast cancer using 66300-1-Ig

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (Progesterone Receptor antibody) at dilution of 1:9900 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

• 

  IHC staining of human breast cancer using 66300-1-Ig

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (Progesterone Receptor antibody) at dilution of 1:10000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Mammakarzinomgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:5000-1:15000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• IHC: See 2 publications below

Produktinformation

66300-1-Ig bindet in IHC, ELISA Progesterone Receptor und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Progesterone Receptor fusion protein Ag22992
• Vollständiger Name: progesterone receptor
• Berechnetes Molekulargewicht: 933 aa, 99 kDa
• GenBank-Zugangsnummer: NM_000926
• Gene symbol: Progesterone Receptor
• Gene ID (NCBI): 5241
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PGR (Progesterone Receptor), also named as NR3C3 and PR, belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Publikationen

Species	Application	Title
human	IHC	Ann Med; Organoids from patient biopsy samples can predict the response of BC patients to neoadjuvant chemotherapy; Authors - Dan Shu
human	IHC	Mol Med Rep; HPK1 positive expression associated with longer overall survival in patients with estrogen receptor-positive invasive ductal carcinoma‑not otherwise specified.; Authors - Jiaojiao Wang