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SCNN1G Polyklonaler Antikörper

SCNN1G Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13943-1-AP

Synonyme

ENaCg, ENaCgamma, Gamma ENaC, Gamma NaCH, PHA1, SCNEG, SCNN1G

Galerie der Validierungsdaten

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  • Immunohistochemistry (IHC) staining of mouse cerebellum tissue using SCNN1G Polyclonal antibody (13943-1-AP)

    IHC staining of mouse cerebellum using 13943-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 13943-1-AP (SCNN1G antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse cerebellum tissue using SCNN1G Polyclonal antibody (13943-1-AP)

    IHC staining of mouse cerebellum using 13943-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 13943-1-AP (SCNN1G antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Geprüfte Anwendungen

Erfolgreiche Detektion in IHCMaus-Cerebellum-Gewebe
Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

AnwendungVerdünnung
Immunhistochemie (IHC)IHC : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

WBSee 5 publications below
IHCSee 6 publications below

Produktinformation

13943-1-AP bindet in WB, IHC, ELISA SCNN1G und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SCNN1G fusion protein Ag5020
Vollständiger Name sodium channel, nonvoltage-gated 1, gamma
Berechnetes Molekulargewicht 74 kDa
Beobachtetes Molekulargewicht 70-85 kDa
GenBank-ZugangsnummerBC059391
Gene symbol SCNN1G
Gene ID (NCBI) 6340
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SCNN1G (sodium channel, nonvoltage-gated 1, gamma), also known as ENaC gamma (epithelial Na(+) channel subunit gamma) or amiloride-sensitive sodium channel subunit gamma, is the gamma subunit of the epithelial Na(+) channel (ENaC). ENaC is expressed in the apical membrane of salt-absorbing epithelia of kidney, distal colon, and lung. ENaC is a non-voltage gated, constitutively active channel highly selective for sodium. It has an essential role in salt and fluid homeostasis across epithelial tissues. Mutations in the gene of SCNN1G have been associated with Liddle syndrome. Native SCNN1G has a calculated molecular weight of 74 kDa and maybe undergo post-transcriptional modifications, including glycosylation and proteolytic cleavage (PMID: 12871941; 18086683).

Protokolle

Produktspezifische Protokolle
IHC protocol for SCNN1G antibody 13943-1-APProtokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
mouseWB

Hypertension

Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.

Authors - Shuai Shao
View Article
mouseIHC

Int J Mol Sci

MST3 Involvement in Na+ and K+ Homeostasis with Increasing Dietary Potassium Intake.

Authors - Chee-Hong Chan
View Article
humanWB

Endocr Relat Cancer

Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism.

Authors - Marcela Rassi-Cruz
View Article
humanIHC

PLoS One

Reduced Expression of Enac in Placenta Tissues of Patients with Severe Preeclampsia Is Related to Compromised Trophoblastic Cell Migration and Invasion during Pregnancy.

Authors - Wang Shan S
View Article
mouseWB,IHC

Respir Physiol Neurobiol

Contribution of concentration-sensitive sodium channels to the absorption of alveolar fluid in mice.

Authors - Teruki Hagiwara
View Article
mouseWB

Exp Anim

Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway.

Authors - Bingji Jin
View Article