SLC16A2 Polyklonaler Antikörper

SLC16A2 Polyklonal Antikörper für WB,ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen

6

Kat-Nr. : 20676-1-AP

Synonyme

AHDS, DXS128, DXS128E, MCT 7, MCT 8, MCT7, MCT8, Monocarboxylate transporter 7, Monocarboxylate transporter 8, MRX22, SLC16A2, XPCT

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Galerie der Validierungsdaten

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  WB analysis of mouse kidney using 20676-1-AP

  mouse kidney tissue were subjected to SDS PAGE followed by western blot with 20676-1-AP (SLC16A2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse heart using 20676-1-AP

  mouse heart tissue were subjected to SDS PAGE followed by western blot with 20676-1-AP (SLC16A2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse heart using 20676-1-AP

  mouse heart tissue were subjected to SDS PAGE followed by western blot with 20676-1-AP (SLC16A2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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  WB analysis of L02 using 20676-1-AP

  L02 cells were subjected to SDS PAGE followed by western blot with 20676-1-AP (SLC16A2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Mausnierengewebe, L02-Zellen, Mausherzgewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 6 publications below

Produktinformation

20676-1-AP bindet in WB, ELISA SLC16A2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
• Berechnetes Molekulargewicht: 60 kDa
• Beobachtetes Molekulargewicht: 50-65 kDa
• GenBank-Zugangsnummer: NM_006517
• Gene symbol: SLC16A2
• Gene ID (NCBI): 6567
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SLC16A2, also named as MCT8 and XPCT, belongs to the major facilitator superfamily and Monocarboxylate porter (TC 2.A.1.13) family. SLC16A2 is a very active and specific thyroid hormone transporter. SLC16A2 stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. It does not transport Leu, Phe, Trp or Tyr. Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency). This antibody is specific to SLC16A2.

Publikationen

Species	Application	Title
mouse	WB	Int J Mol Sci; Smoothelin-Like Protein 1 Regulates the Thyroid Hormone-Induced Homeostasis and Remodeling of C2C12 Cells via the Modulation of Myosin Phosphatase.; Authors - Evelin Major
human	WB	Front Pharmacol; Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1.; Authors - Xue Zhao
mouse	WB	PLoS One; Tissue-Specific Expression of Monocarboxylate Transporters during Fasting in Mice.; Authors - Alexandra Schutkowski
rat	WB	Pharm Res; Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier.; Authors - Ryuta Jomura
human	WB	Toxicology; MiR-24-3p/Dio3 axis is essential for BDE47 to induce local thyroid hormone disorder and neurotoxicity; Authors - Min Liu
human	WB	Toxicology; BDE209-promoted Dio2 degradation in H4 glioma cells through the autophagy pathway, resulting in hypothyroidism and leading to neurotoxicity; Authors - Min Liu