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TMEM106B (1-46aa) Monoklonaler Antikörper

TMEM106B (1-46aa) Monoklonal Antikörper für WB, IP, ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, IF, IP, ELISA

Konjugation

Unkonjugiert

Publikationen(8)

CloneNo.

5D1F8

Kat-Nr. : 60333-1-Ig

Synonyme

TMEM106B, 5D1F8, Transmembrane protein 106B



Geprüfte Anwendungen

Erfolgreiche Detektion in WBU2OS-Zellen, A549-Zellen, HeLa-Zellen, Jurkat-Zellen, K-562-Zellen, LNCaP-Zellen
Erfolgreiche IPHeLa-Zellen

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:5000-1:50000
Immunpräzipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

60333-1-Ig bindet in WB, IF, IP, ELISA TMEM106B (1-46aa) und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen TMEM106B (1-46aa) fusion protein Ag21448
Vollständiger Name transmembrane protein 106B
Berechnetes Molekulargewicht 31 kDa
Beobachtetes Molekulargewicht ~40 kDa
GenBank-ZugangsnummerBC033901
Gene symbol TMEM106B
Gene ID (NCBI) 54664
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression.

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
WB protocol for TMEM106B (1-46aa) antibody 60333-1-IgProtokoll herunterladen
IP protocol for TMEM106B (1-46aa) antibody 60333-1-IgProtokoll herunterladen
STANDARD-PROTOKOLLE
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
human

Cell

Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.

Authors - Andrew Chang
humanWB

Brain

C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes

Authors - Cristina T Vicente
humanWB

Pathol Res Pract

TESC acts as a prognostic factor and promotes epithelial-mesenchymal transition progression in esophageal squamous carcinoma

Authors - Yanxin Dong
humanWB,IP,IF

F1000Res

The identification of high-performing antibodies for transmembrane protein 106B (TMEM106B) for use in Western blot, immunoprecipitation, and immunofluorescence

Authors - Riham Ayoubi
  • KO Validated
humanWB

FASEB J

Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability

Authors - Di Guo
HumanIF

Life Med

Tracing TMEM106B fibril deposition in aging and Parkinson's disease with dementia brains

Authors - Wanbing Zhao