Anticorps Polyclonal de lapin anti-C1QA
C1QA Polyclonal Antibody for WB, IF/ICC, ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain
Applications
WB, IF/ICC, ELISA
Conjugaison
Non conjugué
N° de cat : 11602-1-AP
Synonymes
Galerie de données de validation
Applications testées
| Résultats positifs en WB | plasma humain, tissu cardiaque humain, tissu de côlon humain, tissu hépatique humain, tissu pulmonaire humain, tissu splénique humain |
| Résultats positifs en IF/ICC | cellules HepG2, |
Dilution recommandée
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:8000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Applications publiées
| WB | See 13 publications below |
| IF | See 5 publications below |
Informations sur le produit
11602-1-AP cible C1QA dans les applications de WB, IF/ICC, ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Réactivité citée | Humain |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Polyclonal |
| Type | Anticorps |
| Immunogène | C1QA Protéine recombinante Ag2141 |
| Nom complet | complement component 1, q subcomponent, A chain |
| Masse moléculaire calculée | 245 aa, 26 kDa |
| Poids moléculaire observé | 26-30 kDa |
| Numéro d’acquisition GenBank | BC030153 |
| Symbole du gène | C1QA |
| Identification du gène (NCBI) | 712 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par affinité contre l'antigène |
| Tampon de stockage | PBS with 0.02% sodium azide and 50% glycerol |
| Conditions de stockage | Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
The first component of complement, C1, is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. This antibody is raised against C1qA which is the A-chain polypeptide of human complement subcomponent C1q.
Protocole
| Product Specific Protocols | |
|---|---|
| WB protocol for C1QA antibody 11602-1-AP | Download protocol |
| IF protocol for C1QA antibody 11602-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Brain Behav Immun PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice | ||
Neuron TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4 | ||
Cell Mol Life Sci Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson's disease | ||
Life Sci Cognitive impairment in Alzheimer's disease FAD4T mouse model: Synaptic loss facilitated by activated microglia via C1qA | ||
CNS Neurosci Ther STING Driving Synaptic Phagocytosis of Hippocampal Microglia/Macrophages Contributes to Cognitive Impairment in Sepsis-Associated Encephalopathy in Mice |







