Anticorps Polyclonal de lapin anti-CADM1

CADM1 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications

4

N° de cat : 14335-1-AP

Synonymes

BL2, CADM1, cell adhesion molecule 1, IGSF4, IGSF4A, Necl 2, NECL2, Nectin like protein 2, RA175, sgIGSF, ST17, sTSLC 1, SYNCAM, synCAM1, TSLC 1, TSLC1

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Galerie de données de validation

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  WB analysis of mouse liver using 14335-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 14335-1-AP (CADM1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse lung using 14335-1-AP

  mouse lung tissue were subjected to SDS PAGE followed by western blot with 14335-1-AP (CADM1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  WB analysis of A549 using 14335-1-AP

  A549 cells were subjected to SDS PAGE followed by western blot with 14335-1-AP (CADM1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  WB analysis of human placenta using 14335-1-AP

  human placenta tissue were subjected to SDS PAGE followed by western blot with 14335-1-AP (CADM1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu hépatique de souris, cellules A549, tissu placentaire humain, tissu pulmonaire de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 4 publications below

Informations sur le produit

14335-1-AP cible CADM1 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CADM1 Protéine recombinante Ag5621
• Nom complet: cell adhesion molecule 1
• Masse moléculaire calculée: 49 kDa
• Poids moléculaire observé: 49-60 kDa
• Numéro d’acquisition GenBank: BC047021
• Symbole du gène: CADM1
• Identification du gène (NCBI): 23705
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CADM1 (cell adhesion molecule 1), also referred to as SgIGSF, Necl-2 or TSLC-1, is a cell adhesion molecule belonging to the immunoglobulin superfamily. It can mediate homophilic and heterophilic cell-cell adhesion. CADM1 is expressed by a variety of cells including neurons, mast cells, spermatogonia, pancreatic islet cells, epithelial cells such as lung alveolar cells and biliary epithelial cells. CADM1 is involved in carcinoma pathogenesis and the expression of CADM1 is frequently down-regulated in various tumors derived from epithelial cells. It acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. (PMID: 18332875; 17326163; 20340131)

Publications

Species	Application	Title
mouse	WB	PLoS One; Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination.; Authors - Zhu Ying Y
human	WB	Onco Targets Ther; miR-424-5p Promotes Proliferation, Migration and Invasion of Laryngeal Squamous Cell Carcinoma.; Authors - Yujun Li
human	WB	Oncol Lett; miR-214-3p promotes the proliferation, migration and invasion of osteosarcoma cells by targeting CADM1.; Authors - Haiqing Cai
human	WB	BMC Cancer; CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells; Authors - Bei Xie

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