Anticorps Polyclonal de lapin anti-CALCR

CALCR Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications(6)

N° de cat : 20868-1-AP

Synonymes

calcitonin receptor, CRT, CT R, CTR, CT-R

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Galerie de données de validation

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  WB analysis using 20868-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 20868-1-AP (CALCR antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules MCF-7, cellules PC-12, tissu cérébral de souris, tissu rénal de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 6 publications below

Informations sur le produit

20868-1-AP cible CALCR dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CALCR Protéine recombinante Ag14920
• Nom complet: calcitonin receptor
• Masse moléculaire calculée: 490 aa, 57 kDa
• Poids moléculaire observé: 70 kDa
• Numéro d’acquisition GenBank: BC075028
• Symbole du gène: CALCR
• Identification du gène (NCBI): 799
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

The CALCR protein, also known as the calcitonin receptor, is a high-affinity receptor for the peptide hormone calcitonin and belongs to the subfamily of seven transmembrane-spanning G protein-coupled receptors. This protein plays a critical role in maintaining calcium homeostasis and regulating osteoclast-mediated bone resorption. The calcitonin receptor is involved in several physiological processes, including inhibition of osteoclastic bone resorption and increased renal calcium excretion, which helps to regulate Ca2+ concentrations. In addition, the CALCR protein has been detected in a variety of tissues not directly involved in the regulation of calcium homeostasis, with particular expression observed in the brain, suggesting distinct functions in the central nervous system (CNS) (PMID: 12730726).

Publications

Species	Application	Title
	WB	J Cell Mol Med; Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.; Authors - Zhi Qian
human	WB	Mol Med; A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.; Authors - Yu Fu
human	WB	Curr Issues Mol Biol; COPS5 Conferred the Platinum Resistance in Epithelial Ovarian Cancer; Authors - Ming-Wei Lin
human	WB	Adv Sci (Weinh); Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening.; Authors - Fangyuan Shao
mouse	WB	Nat Commun; Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics; Authors - Xi Shao
mouse	WB	Cell Metab; Gut microbial alterations in arginine metabolism determine bone mechanical adaptation; Authors - Dan Wang

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