Anticorps Polyclonal de lapin anti-CLEC2/CLEC1B

CLEC2/CLEC1B Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

Publications(2)

Avis (1)

N° de cat : 12814-1-AP

Synonymes

1810061I13Rik, C type lectin like receptor 2, CLEC 2, CLEC1B, CLEC2, CLEC2B, PRO1384, QDED721

---

Galerie de données de validation

• 

  WB analysis of human peripheral blood platelets using 12814-1-AP

  human peripheral blood platelets were subjected to SDS PAGE followed by western blot with 12814-1-AP (CLEC2/CLEC1B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

---

Applications testées

• Résultats positifs en WB: plaquettes de sang périphérique humain,

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• IHC: See 1 publications below

Informations sur le produit

12814-1-AP cible CLEC2/CLEC1B dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CLEC2/CLEC1B Protéine recombinante Ag3512
• Nom complet: C-type lectin domain family 1, member B
• Masse moléculaire calculée: 27 kDa
• Poids moléculaire observé: 32-38 kDa
• Numéro d’acquisition GenBank: BC029554
• Symbole du gène: CLEC2
• Identification du gène (NCBI): 51266
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

C-type lectin-like receptor 2 (CLEC2, also known as CLEC1B) is a type II transmembrane receptor of the C-type lectin superfamily, which are characterized by one or more C-type lectin-like domains (CTLDs) (PMID: 10671229; 34177942). CLEC2 contains a single YXXL/hemi-ITAM (immuno-receptor tyrosine-based activation motif) within its cytoplasmic domain. CLEC-2 is highly expressed on platelets and megakaryocytes and at low levels on other hematopoietic cells, including dendritic cells, neutrophils, monocytes, and macrophages (PMID: 21728173). The first identified ligand for CLEC2 was the platelet-aggregating snake venom protein rhodocytin, and podoplanin has been established as an endogenous ligand for CLEC2 (PMID: 26151067). CLEC2 is involved in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis (PMID: 20525685). CLEC2 can be glycosylated and has been detected as 32- and 40-kDa forms in platelets with varying degrees of glycosylation (PMID: 16174766; 25150298; 21781241).

Publications

Species	Application	Title
		EMBO Mol Med; Histidine-rich glycoprotein modulates neutrophils and thrombolysis-associated hemorrhagic transformation; Authors - Wei Jiang
human	IHC	Int J Gen Med; CLEC1B is a Promising Prognostic Biomarker and Correlated with Immune Infiltration in Hepatocellular Carcinoma.; Authors - Xiaoliang Liang

Avis

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.

---

FH

Smita (Verified Customer) (07-23-2025)

Works very well for fluorescence imaging in human platelets.

• Applications: Immunofluorescence
• Primary Antibody Dilution: 1 in 80
• Cell Tissue Type: Platelets

{{ptg:RelatedPrimaryAntibodies}}