Anticorps Polyclonal de lapin anti-CXCL17

CXCL17 Polyclonal Antibody for IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (1)

Applications

WB, IHC, IF, ELISA

Conjugaison

Non conjugué

Publications(8)

N° de cat : 18108-1-AP

Synonymes

Dendritic cell and monocyte chemokine-like protein, Dcip1, C-X-C motif chemokine 17, C X C motif chemokine 17, 6-Cys CXCL17



Applications testées

Résultats positifs en IHCtissu de cancer du côlon humain, tissu de cancer de l'estomac humain, tissu de cancer du foie humain, tissu de cancer du sein humain
il est suggéré de démasquer l'antigène avec un tampon de TE buffer pH 9.0; (*) À défaut, 'le démasquage de l'antigène peut être 'effectué avec un tampon citrate pH 6,0.

Dilution recommandée

ApplicationDilution
Immunohistochimie (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

18108-1-AP cible CXCL17 dans les applications de WB, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Réactivité citéeHumain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène CXCL17 Protéine recombinante Ag12516
Nom complet chemokine (C-X-C motif) ligand 17
Masse moléculaire calculée 119 aa, 14 kDa
Numéro d’acquisition GenBankBC093946
Symbole du gène CXCL17
Identification du gène (NCBI) 284340
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS with 0.02% sodium azide and 50% glycerol
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CXCL17, also known as C-X-C motif chemokine 17, is a relatively newly discovered member of the CXC chemokine family, which plays a multifaceted role in immune responses and other biological processes. CXCL17 has been implicated in several human pathologies, and its role in mediating immune responses is of particular interest. It is involved in the recruitment of immune cells, angiogenesis, and control of microorganisms at mucosal barriers . It is also known to be involved in tumor angiogenesis and has shown both proinflammatory and anti-inflammatory effects. CXCL17 is highly expressed in the gastric mucosa and other mucosal tissues. Its receptor was identified as GPR35 and named CXCR8, although the functional role of this interaction is not yet fully understood. CXCL17's expression is associated with both disease progression and protection in various diseases. It has been linked to pulmonary fibrosis, asthma, lung cancer, and hepatic cancer, where increased expression is associated with disease progression. Conversely, it may play a protective role in pancreatic cancer, autoimmune encephalomyelitis, and viral infections. Research has shown that CXCL17 promotes neutrophil trafficking and plays a role in the early proinflammatory response by facilitating the recruitment of neutrophils to the site of insult . It also exhibits chemoattractant abilities targeting monocytes and macrophages and can induce the production of proangiogenic factors such as vascular endothelial growth factor A from treated monocytes

Protocole

Product Specific Protocols
IHC protocol for CXCL17 antibody 18108-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Nat Commun

Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis.

Authors - Xiannian Zhang
humanIHC, WB, IF

J Dermatol Sci

CXCL17-mediated downregulation of type I collagen via MMP1 and miR-29 in skin fibroblasts possibly contributes to the fibrosis in systemic sclerosis.

Authors - Shuichi Shimada
humanIHC

Cancers (Basel)

A Novel Risk Score Model of Lactate Metabolism for Predicting over Survival and Immune Signature in Lung Adenocarcinoma

Authors - Zhou Jiang
humanWB

Metab Brain Dis

Sequencing and Bioinformatics analysis of lncRNA/circRNA-miRNA-mRNA in Glioblastoma multiforme

Authors - Renjie Wang
humanWB,IHC

Curr Issues Mol Biol

Loss of CCL28 and CXCL17 Expression and Increase in CCR1 Expression May Be Related to Malignant Transformation of LGBLEL into Lymphoma

Authors - Rui Liu
humanWB,IHC

Int J Med Sci

OCT4 promotes lung cancer progression through upregulation of VEGF-correlated chemokine-1

Authors - Bing-Hua Su
  • KD Validated
{{ptg:RelatedPrimaryAntibodies}}