Anticorps Polyclonal de lapin anti-CXCL2

CXCL2 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (1)

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

Publications(6)

N° de cat : 16325-1-AP

Synonymes

Growth-regulated protein beta, GRO-beta(5-73), Gro-beta, CXCL 2, C-X-C motif chemokine 2

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Galerie de données de validation

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  WB analysis using 16325-1-AP

  Human lung tissue was subjected to SDS PAGE followed by western blot with 16325-1-AP (CXCL2 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu pulmonaire humain

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 2 publications below
• IHC: See 4 publications below

Informations sur le produit

16325-1-AP cible CXCL2 dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CXCL2 Protéine recombinante Ag9410
• Nom complet: chemokine (C-X-C motif) ligand 2
• Masse moléculaire calculée: 107 aa, 11 kDa
• Poids moléculaire observé: 9 kDa
• Numéro d’acquisition GenBank: BC015753
• Symbole du gène: CXCL2
• Identification du gène (NCBI): 2920
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CXCL2, also known as macrophage inflammatory protein 2-alpha (MIP2-alpha), is a member of CXC chemokine family that binds to CXC chemokine receptor 2 (CXCR2). CXCL2 is mainly produced by macrophages, endothelial cells, epithelial cells and tumor cells. CXCL2 plays important roles in various biological progresses such as angiogenesis, inflammation, immune response and cancer biological behaviors. Under inflammatory conditions in CNS, microglia and astrocytes may secrete CXCL2 as well as other chemokines, which induces chemotaxis and infiltration of circulatory neutrophils. Indeed, previous studies suggest that CXCL2 is involved in Alzheimer disease, multiple sclerosis and brain ischemia.

Publications

Species	Application	Title
human	IHC	Adv Sci (Weinh); Targeting Deltex E3 Ubiquitin Ligase 2 Inhibits Tumor-associated Neutrophils and Sensitizes Hepatocellular Carcinoma Cells to Immunotherapy; Authors - Xiaoling Wu
mouse	WB	Int Immunopharmacol; GL13K-modified titanium regulates osteogenic differentiation via the NF-κB pathway; Authors - Yu Han
mouse	IHC	Bioorg Chem; Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression; Authors - Xu Zhou
human	IHC	Transl Cancer Res; Correlations of AKIP1, CXCL1 and CXCL2 expressions with clinicopathological features and survival profiles in cervical cancer patients; Authors - Xiaoyan Wan
mouse	WB	Front Cell Dev Biol; Molecular dynamics of chemotactic signalling orchestrates dental pulp stem cell fibrosis during aging; Authors - Tianmeng Sun
human,mouse	IHC	Int Immunopharmacol; Langhans giant cells regulate cutaneous immune responses during mycobacterial infection through CXCL1/CXCL2 secretion; Authors - Yumeng Jiang

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