Anticorps Polyclonal de lapin anti-DCC-Specific

DCC-Specific Polyclonal Antibody for WB,ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications

2

N° de cat : 19123-1-AP

Synonymes

Colorectal cancer suppressor, CRC18, CRCR1, DCC, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC

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Galerie de données de validation

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  WB analysis of mouse brain using 19123-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 19123-1-AP (DCC-Specific Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below
• IF: See 1 publications below

Informations sur le produit

19123-1-AP cible DCC-Specific dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: deleted in colorectal carcinoma
• Masse moléculaire calculée: 1447 aa, 158 kDa
• Poids moléculaire observé: 180 kDa
• Numéro d’acquisition GenBank: NM_005215
• Symbole du gène: DCC
• Identification du gène (NCBI): 1630
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody raised against a synthesized polypeptide of human DCC protein recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).

Publications

Species	Application	Title
mouse	WB	Aging (Albany NY); PMID: 32271715; Authors - Dongdong Chai
mouse	IF	Sci Rep; The expression of Netrin-1 in the MIA-induced osteoarthritic temporomandibular joint in mice.; Authors - Mian Xiao

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