Anticorps Monoclonal anti-DCC-Specific

DCC-Specific Monoclonal Antibody for WB, ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, souris

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(2)

CloneNo.

2G4G4

N° de cat : 67203-1-Ig

Synonymes

Colorectal cancer suppressor, CRC18, CRCR1, DCC, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC

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Galerie de données de validation

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  WB analysis of mouse brain using 67203-1-Ig

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 67203-1-Ig (DCC-Specific antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris,

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 2 publications below
• IF: See 2 publications below

Informations sur le produit

67203-1-Ig cible DCC-Specific dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Réactivité citée: souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: DCC-Specific Protéine recombinante Ag20569
• Nom complet: deleted in colorectal carcinoma
• Masse moléculaire calculée: 1447 aa, 158 kDa
• Poids moléculaire observé: 180 kDa
• Numéro d’acquisition GenBank: NM_005215
• Symbole du gène: DCC
• Identification du gène (NCBI): 1630
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20 ℃. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC plays a key role in the developing nervous system. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).

Publications

Species	Application	Title
mouse	WB,IF	J Ethnopharmacol; Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses; Authors - Jiamin Hu
mouse	WB,IF	Neurobiol Stress; DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress; Authors - Shaojie Yang

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