Anticorps Recombinant de lapin anti-IL-23 p19

IL-23 p19 Recombinant Antibody for FC (Intra)

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC (Intra)

Conjugaison

Non conjugué

CloneNo.

242139G12

N° de cat : 98392-1-RR

Synonymes

IL-23 subunit alpha, Il23a, IL-23A, IL-23-A, IL23P19

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98392-1-RR

  1x10^6 HEK-293T cells(left) and IL23A -transfected HEK-293T cells(right) were stained with 0.25 ug Anti-Mouse IL23A Rabbit RecAb (98392-1-RR, Clone:242139G12) and APC-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).

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  FC experiment of Transfected HEK-293T using 98392-1-RR

  1x10^6 HEK-293T cells(left) and IL23A -transfected HEK-293T cells(right) were stained with 0.25 ug Anti-Mouse IL23A Rabbit RecAb (98392-1-RR, Clone:242139G12)(red), or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).

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Applications testées

• Résultats positifs en FC (Intra): Transfected HEK-293T cells,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98392-1-RR cible IL-23 p19 dans les applications de FC (Intra) et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-23 p19 Protéine recombinante Eg1634
• Nom complet: interleukin 23, alpha subunit p19
• Masse moléculaire calculée: 22 kDa
• Numéro d’acquisition GenBank: NM_031252.2
• Symbole du gène: Il23a
• Identification du gène (NCBI): 83430
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).

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