Anticorps Polyclonal de lapin anti-L1CAM/CD171

L1CAM/CD171 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

Publications(5)

N° de cat : 20659-1-AP

Synonymes

L1CAM, CAML1, CD171, HSAS, HSAS1



Applications testées

Résultats positifs en WBtissu cérébral de souris, tissu cérébral de rat

Dilution recommandée

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

20659-1-AP cible L1CAM/CD171 dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Réactivité citéeHumain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet L1 cell adhesion molecule
Masse moléculaire calculée 140 kDa
Poids moléculaire observé 200-220 kDa, 80 kDa
Numéro d’acquisition GenBankNM_000425
Symbole du gène L1CAM
Identification du gène (NCBI) 3897
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS with 0.02% sodium azide and 50% glycerol
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

L1CAM, also known as NCAM-L1 or CD171, is a cell adhesion molecule of the immunoglobulin superfamily. It is a 200-220 kDa transmembrane glycoprotein composed of six Ig-like domains and five fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail (PMID: 3412448; 22796939). L1CAM is primarily expressed in the nervous system and is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts (PMID: 3412448; 10767310). L1CAM is overexpressed in many human cancers and is often associated with bad prognosis (PMID: 27267927; 26111503). It has been reported that L1CAM can be proteolytically cleaved into a soluble fragment of 140 kDa and an intracellular fragment of 80-85 kDa (PMID: 30842511; 34380733). This antibody raised against 1206-1221aa of human L1CAM detects 200-220 kDa full-length L1CAM and 80-kDa cleaved fragment of L1CAM.

Protocole

Product Specific Protocols
WB protocol for L1CAM/CD171 antibody 20659-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Histopathology

Frequent KRAS mutations in oncocytic papillary renal neoplasm with inverted nuclei.

Authors - Kuo Tong
humanWB

Diagnostics (Basel)

Circulatory Astrocyte and Neuronal EVs as Potential Biomarkers of Neurological Dysfunction in HIV-Infected Subjects and Alcohol/Tobacco Users.

Authors - Sunitha Kodidela
human

Anal Chem

Nanosensor-Driven Detection of Neuron-Derived Exosomal Aβ42 with Graphene Electrolyte-Gated Transistor for Alzheimer's Disease Diagnosis

Authors - Jiahao Li
mouseWB

Res Sq

Curcumin enhances elvitegravir concentration and alleviates oxidative stress and inflammatory response

Authors - Sandip Godse
mouseWB

Sci Rep

Curcumin enhances elvitegravir concentration and alleviates oxidative stress and inflammatory response

Authors - Sandip Godse
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