Anticorps Polyclonal de lapin anti-NUPL2

NUPL2 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications(1)

N° de cat : 16587-1-AP

Synonymes

CG1, hCG1, NLP 1, NLP_1, NLP1, Nucleoporin hCG1, nucleoporin like 2, Nucleoporin like protein 2, NUP42 homolog, NUPL2

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Galerie de données de validation

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  WB analysis of HEK-293 using 16587-1-AP

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 16587-1-AP (NUPL2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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  WB analysis of human liver using 16587-1-AP

  human liver tissue were subjected to SDS PAGE followed by western blot with 16587-1-AP (NUPL2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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  WB analysis of L02 using 16587-1-AP

  L02 cells were subjected to SDS PAGE followed by western blot with 16587-1-AP (NUPL2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules HEK-293, cellules L02, tissu hépatique humain

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below

Informations sur le produit

16587-1-AP cible NUPL2 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: NUPL2 Protéine recombinante Ag8816
• Nom complet: nucleoporin like 2
• Masse moléculaire calculée: 45 kDa
• Poids moléculaire observé: 45 kDa, 33-36 kDa
• Numéro d’acquisition GenBank: BC005327
• Symbole du gène: NUPL2
• Identification du gène (NCBI): 11097
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

NUPL2 (also known as NLP-1, or hCG1) is an ubiquitous nuclear protein containing many phenylalanine-glycine (FG) repeats. As the functional orthologue of the budding yeast Nup42/Rip1 nucleoporin, NUPL2 is required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm (PMID: 10610322). In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope (PMID: 16000379). NUPL2 localizes to the nuclear envelope and could also be mobile within the nucleus. It promotes CRM1-dependent nuclear protein export (PMID: 22250199).

Publications

Species	Application	Title
human	WB	Front Cell Dev Biol; Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length; Authors - Maciej Kliszczak

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