Anticorps Polyclonal de lapin anti-TIPIN

TIPIN Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

Publications(2)

N° de cat : 11972-2-AP

Synonymes

TIMELESS interacting protein, TIPIN

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Galerie de données de validation

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  WB analysis using 11972-2-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 11972-2-AP (TIPIN antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris, tissu cérébral de rat

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 1 publications below
• WB: See 1 publications below
• IHC: See 1 publications below

Informations sur le produit

11972-2-AP cible TIPIN dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TIPIN Protéine recombinante Ag2595
• Nom complet: TIMELESS interacting protein
• Masse moléculaire calculée: 301 aa, 34 kDa
• Poids moléculaire observé: 48 kDa
• Numéro d’acquisition GenBank: BC000870
• Symbole du gène: TIPIN
• Identification du gène (NCBI): 54962
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

TIPIN, also named as TIMELESS-interacting protein, is a 301 amino acid protein, which belongs to the CSM3 family. TIPIN Plays an important role in the control of DNA replication and the maintenance of replication fork stability. TIPIN forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. The calculated molecular weight of TIPIN is 34 kDa, but the result of WB is 55-60 kDa, which is similar to the result of publication.(PMID: 24830473)

Publications

Species	Application	Title
human	IHC	Dis Markers; Integrated Bioinformatic Analysis Identifies TIPIN as a Prognostic Biomarker in Hepatocellular Carcinoma.; Authors - Hui Chen
human	WB	Nature; Mechanism for local attenuation of DNA replication at double-strand breaks; Authors - Robin Sebastian ; KD Validated

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