Recombinant Mouse Transferrin R protein (His tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
His tag
Activity
not tested
Cat no : Eg1064
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse Transferrin R protein Cys89-Phe763 (Accession# Q62351) with a His tag at the N-terminus. |
| GeneID | 22042 |
| Accession | Q62351 |
| PredictedSize | 77.0 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
CD71, also known as transferrin receptor protein 1 (TfR1) is a type II cell membrane-associated glycoprotein involved in iron homeostasis and cell growth. CD71 is commonly upregulated in cells with high proliferative index, including cancer cells that need iron as cofactor of many enzymatic reactions, such as DNA synthesis. CD71 overexpression has been reported in several human malignant tumors, including lymphomas, carcinomas, neuroendocrine, and brain tumors.
References:
1. Daniels, Tracy R et al. Biochimica et biophysica acta vol. 1820,3 (2012): 291-317. 2. Daniels, Tracy R et al. Clinical immunology (Orlando, Fla.) vol. 121,2 (2006): 159-76. 3. Pantopoulos, Kostas. Annals of the New York Academy of Sciences vol. 1012 (2004): 1-13.