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Recombinant Human CD204 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2566

Validation Data Gallery

  • Purity of Recombinant Human CD204 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD204 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human CD204 protein Lys77-Leu451 (Accession# P21757-1) with a rabbit IgG Fc tag at the N-terminus.
GeneID 4481
Accession P21757-1
PredictedSize 68.5 kDa
SDS-PAGE 75-110 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

MSR1 also known as CD204, belongs to the scavenger receptor family, which is mainly expressed on the surface of macrophages. MSR1 plays a key inflammatory role in various pathophysiological processes, including atherosclerosis, innate and adaptive immunity, lung and liver disease, and cancer. MSR1 binds to a variety of ligands, including modified low-density lipoproteins (LDL) and lipids, and is involved in endocytosis, positive regulation of cholesterol storage, and positive regulation of macrophage-derived foam cell differentiation. Studies have shown that MSR1 is significantly increased in peripheral blood mononuclear cells (PBMCs) from patients with asthma and chronic obstructive pulmonary disease (COPD), which may serve as a disease marker.

References:

1. Olivier Govaere, et al. (2022) J Hepatol. 76(5):1001-1012.
2. Jack Gudgeon, et al. (2022) Front Immunol. 13:1012002.
3. Selene Baos, et al. (2022) J Clin Med. 11(5):1439.