• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Recombinant Mouse Timd4 protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3307

Validation Data Gallery

  • Purity of Recombinant Mouse Timd4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Timd4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse Timd4 protein Ala23-Thr279 (Accession# Q6U7R4) with a rabbit IgG Fc tag at the C-terminus.
GeneID 276891
Accession Q6U7R4
PredictedSize 51.1 kDa
SDS-PAGE 72-95 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

T cell immunoglobulin mucin 4 (Tim4), a macrophage receptor for phosphatidylserine (PtdSer) on apoptotic cells. It is evidenced that TIMD-4 as phosphatidylserine (PS) receptor is capable of maintaining peritoneal macrophages’ homeostatic function and regulating adaptive immunity based on the alteration of Ag-particular T cells’ clearance. It is noteworthy that TIMD-4’s dysregulating process was identified under several autoimmune states, in particular inside immune cells. In addition, TIMD-4 was identified to be over-expressed in Systemic lupus erythematosus (SLE) cases.

References:

1. Kuroiwa Miki, et al. (2023) Sci Total Environ. 875 : 162586.
2.Yang Zhicheng, et al. (2021) Pharmgenomics Pers Med.14:221-228.