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ACTL6B antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB

Activ Motif logo

Cat No : 61691,61692 61691

Synonyms

ACTL6, Actin-Like 6B, BRG1-Associated Factor 53B, ACTL6, Actin-Like Protein 6B, BAF53B, arpNalpha, Actin-Like 6, HArpN Alpha, Actin-Related Protein Baf53b, ArpNalpha, 53 KDa BRG1-Associated Factor B, baf complex, baf, chromatin remodeling, bbaf, nbaf, polyclonal, pab, antibody, antibodies, western blotting, wb, sample

Validation Data Gallery

  • ACTL6B antibody (pAb) tested by Western blot. Whole cell extract of SH-SY5Y cells (12 ug) probed with ACTL6B antibody (pAb) at a dilution of 1:500.

    ACTL6B antibody (pAb) tested by Western blot. Whole cell extract of SH-SY5Y cells (12 ug) probed with ACTL6B antibody (pAb) at a dilution of 1:500.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1:250 - 1:500 dilution
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This antibody was raised against a peptide within the N-terminal region of human ACTL6B.
Full Name ACTL6B antibody (pAb)
Synonyms ACTL6, Actin-Like 6B, BRG1-Associated Factor 53B, ACTL6, Actin-Like Protein 6B, BAF53B, arpNalpha, Actin-Like 6, HArpN Alpha, Actin-Related Protein Baf53b, ArpNalpha, 53 KDa BRG1-Associated Factor B, baf complex, baf, chromatin remodeling, bbaf, nbaf, polyclonal, pab, antibody, antibodies, western blotting, wb, sample
Molecular weight 50 kDa
GenBank accession numberNP_057272
RRIDAB_2793737
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

ACTL6B (Actin-Like 6B) Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).