ADAM8 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 23778-1-AP

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Freight/Packing

Con: 63 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
BxPC-3 cells, mouse pancreas tissue

Positive IHC detected in:
human tonsillitis tissue, human pancreas tissue, human tonsillitis tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ADAM metallopeptidase domain 8

Calculated molecular weight:
824aa,89 kDa

Observed molecular weight:
65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ADAM8

Synonyms
ADAM metallopeptidase domain 8, ADAM8, ADAM8 protein, CD156, MS2
Background

ADAMs are a large family of transmembrane proteins that are involved in proteolysis, making them candidates for mediating the remodeling of the extracellular matrix(ECM). ADAM8, one of the members of the ADAM family, is overexpressed in various human tumors. It has been shown previously that hypoxia influences the expression of some ADAM proteins. The protein found to be expressed in two active forms(90 kDa and 60 kDa): potential shedding protein and remnant protein in the pancreatic tissues under chronic pancreatitis and pancreatic cancer(PMID:18566576). The full length protein has a signal peptide and four glycosylation sites. This antibody is specific to ADAM8.


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