Anti-Human ADAMTS13 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of HUVEC using 98468-2-RR (same clone as 98468-2-PBS)

  1x10^6 HUVEC cells were intracellularly stained with 0.25 ug Anti-Human ADAMTS13 Rabbit RecAb (98468-2-RR, Clone: 250498C4) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98468-2-PBS in a different storage buffer formulation.

ADAMTS13 Uni-rAb^TM Recombinant Antibody for FC (Intra)

Cat No. 98468-2-PBS

Clone No.250498C4

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC (Intra)

Synonyms

ADAM TS 13, ADAM TS13, ADAMTS 13, C9orf8, TTP

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Product Information

98468-2-PBS targets ADAMTS13 in FC (Intra) applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: ADAMTS13 fusion protein Eg2556
• Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 13
• Calculated Molecular Weight: 154 kDa
• GenBank Accession Number: NM_139025
• Gene Symbol: ADAMTS13
• Gene ID (NCBI): 11093
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q76LX8
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13) is a zinc-dependent metalloproteinase that contains multiple domains, such as the signal peptide, propeptide, metalloproteinase domain, disintegrin-like domain, and TSP-1 domain, among others. The primary function of ADAMTS13 is to specifically cleave the ultra-large multimers of von Willebrand factor (vWF), preventing excessive platelet aggregation and the formation of microvascular thrombi. Deficiency of ADAMTS13 is closely associated with thrombotic thrombocytopenic purpura (TTP), a severe disease characterized by thrombocytopenia, microvascular thrombosis, and tissue damage. Additionally, reduced ADAMTS13 activity is also linked to diseases such as myocardial infarction and stroke.