ADRM1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 11468-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 23 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HeLa cells, mouse ovary tissue, mouse testis tissue

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
MCF-7 cells

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
adhesion regulating molecule 1

Calculated molecular weight:
407aa,42 kDa

Observed molecular weight:
46kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ADRM1

Synonyms
adhesion regulating molecule 1, ADRM1, ARM 1, ARM1, GP110, hRpn13, Rpn13, Rpn13 homolog
Background

The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts.


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