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AGGF1 Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 11889-1-AP

Featured Product KD/KO validated

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Con: 40 μg/150 μl

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Tested Applications

Applications:
WB, IHC, IF, ELISA
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Images See all

AGGF1 Antibody WB mouse liver tissue 11889-1-AP

mouse liver tissue were subjected to SDS PAGE followed by western blot with 11889-1-AP(AGGF1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours

AGGF1 Antibody IHC human spleen tissue 11889-1-AP

Immunohistochemical analysis of paraffin-embedded human spleen using 11889-1-AP(AGGF1 antibody) at dilution of 1:25 (under 40x lens)

Species specificity:
human, mouse, rat
Positive WB detected in:
mouse liver tissue, HEK-293 cells, HeLa cells, rat liver tissue
Positive IHC detected in:
human spleen tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
WB : 1:500-1:2000
IHC : 1:10-1:100
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
AGGF1 fusion protein Ag2497
Full name:
angiogenic factor with G patch and FHA domains 1
Calculated molecular weight:
714aa,81 kDa
Observed molecular weight:
84-100 kDa
GenBank accession number:
BC029382
Gene ID (NCBI):
55109
Gene symbol
AGGF1
Synonyms
AGGF1, Angiogenic factor VG5Q, GPATC7, GPATCH7, HSU84971, HUS84971, hVG5Q, VG5Q

Background

The angiogenic factor gene, AGGF1 (or VG5Q), is identified as a candidate susceptibility gene for Klippel-Trenaunay syndrome (KTS) which is a severe congenital disorder characterized by capillary malformations, venous malformations or varicose veins, and hypertrophy of the affected tissues. AGGF1 protein can bind to endothelial cells and promote cell proliferation. AGGF1 shows strong expression in blood vessels and is secreted as vessel formation is initiated. Regulation of AGGF1 by GATA1 may play roles in endothelial cell biology and angiogenesis. Catalog#11889-1-AP was validated by KO and KD methods in scientists' studies (PMID: 28153879; 27513923), and the observed MW is 84 kDa.


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