ALDH1L2 Polyclonal antibody
ALDH1L2 Polyclonal Antibody for IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
human, mouse, rat
WB, IHC, ELISA
Cat no : 21391-1-AP
|Positive WB detected in||mouse pancreas tissue, rat pancreas tissue|
|Positive IHC detected in||human pancreas tissue, human heart tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:3000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
21391-1-AP targets ALDH1L2 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ALDH1L2 fusion protein Ag16046|
|Full Name||aldehyde dehydrogenase 1 family, member L2|
|Calculated molecular weight||923 aa, 102 kDa|
|Observed molecular weight||102 kDa, 89 kDa|
|GenBank accession number||BC103935|
|Gene ID (NCBI)||160428|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
ALDH1L2(Aldehyde dehydrogenase family 1 member L2) is also named as mitochondrial 10-FTHFDH, mtFDH and belongs to the aldehyde dehydrogenase family and ALDH1L subfamily. The ALDH1L2 gene has three transcriptional variants with the molecular weight of 102 kDa, 42 kDa and 89 kDa(PMID:19823103). It is a mitochondrial enzyme, a likely source of CO2 production from 10-formyltetrahydrofolate in mitochondria and playing an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell(PMID: 20498374). It also has dehydrogenase/hydrolase activities similar to cytosolic FDH (ALDH1L1). The native ALDH1L2 has been reported to exist as a dimer or tetramer(PMID:7822273).
|Product Specific Protocols|
|WB protocol for ALDH1L2 antibody 21391-1-AP||Download protocol|
|IHC protocol for ALDH1L2 antibody 21391-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis.
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.
Free Radic Biol Med
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.
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Hua (Verified Customer) (08-26-2019)