15 Lipoxygenase 2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 13073-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells, HEK-293 cells

Positive IHC detected in:
human prostate cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
arachidonate 15-lipoxygenase, type B

Calculated molecular weight:
676aa,76 kDa

Observed molecular weight:
76 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ALOX15B

Synonyms
15 Lipoxygenase 2, 15 LOX 2, 15 LOX B, ALOX15B, ALOX8, Arachidonate 15 lipoxygenase B
Background

In humans, there are 6 functional lipoxygenases genes. Two of them encode for arachidonic acid 12-lipoxygenating (ALOX12, ALOX12B) and two for 15-lipoxygenating enzymes (ALOX15, ALOX15B). ALOX15B has been described as the most abundant 15-lipoxygenating enzyme species in human carotid atherosclerotic lesions and to be associated with cerebrovascular symptoms. (PMID:24373925). ALOX15B has 4 isoforms produced by alternative splicing with the MW of 76, 67, 69 and 73 kDa. 13073-1-AP can also recognize the mouse Alox8 protein.


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