5 Lipoxygenase Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 10021-1-Ig

Featured Product KD/KO validated

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Freight/Packing

Con: 79 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HL-60 cells,DU 145 cells

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Protein A purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Recombinant Protein

Full name:
arachidonate 5-lipoxygenase

Calculated molecular weight:
674aa,78 kDa

Observed molecular weight:
~70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ALOX5

Synonyms
5 Lipoxygenase, 5 LO, 5 LOX, 5LPG, ALOX5, LOG5
Background

ALOX5(arachidonate 5-lipoxygenase) is also named as LOG5, 5-LO and belongs to the lipoxygenase family. It catalyzes the first step in leukotriene biosynthesis, and plays a role in inflammatory processes. It is a 78 kDa iron-containing enzyme that translocates from the cytosol to associate with FLAP, and converts arachidonate in two steps into the unstable intermediate LTA4. It is essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma(PMID:12911785).


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