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ACOX1 Antibody 20 Publications

Rabbit Polyclonal| Catalog number: 10957-1-AP

Featured Product KD/KO validated

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Con: 45 μg/150 μl

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Tested Applications

Applications:
WB, IHC, IF, ELISA
Application not tested? Please see our Guarantee


Images See all

ACOX1 Antibody WB mouse kidney tissue 10957-1-AP

mouse kidney tissue were subjected to SDS PAGE followed by western blot with 10957-1-AP(ACOX1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours

ACOX1 Antibody IHC human liver cancer tissue 10957-1-AP

Immunohistochemical analysis of paraffin-embedded human liver cancer using 10957-1-AP(ACOX1 antibody) at dilution of 1:100 (under 10x lens)

ACOX1 Antibody IHC human liver cancer tissue 10957-1-AP

Immunohistochemical analysis of paraffin-embedded human liver cancer using 10957-1-AP(ACOX1 antibody) at dilution of 1:100 (under 40x lens)

Species specificity:
human, mouse, rat
Positive WB detected in:
mouse kidney tissue, mouse liver tissue
Positive IHC detected in:
human liver cancer tissue, human lung cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
Sample-dependent, check data in Validation tab

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
ACOX1 fusion protein Ag1405
Full name:
acyl-Coenzyme A oxidase 1, palmitoyl
Calculated molecular weight:
74 kDa
Observed molecular weight:
50 kDa
GenBank accession number:
BC010425
Gene ID (NCBI):
51
Gene symbol
ACOX1
Synonyms
ACOX, ACOX1, AOX, PALMCOX, Palmitoyl CoA oxidase, SCOX

Background

ACOX1(Peroxisomal acyl-coenzyme A oxidase 1) is the first and rate-limiting enzyme in the peroxisomal fatty acid beta-oxidation pathway and catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It belongs to the acyl-CoA oxidase family and also named as ACOX, AOX, SCOX. It has 3 isoforms produced by alternative splicing with the molecular mass of 70-74 kDa and can be cleaved post-translationally into a 50-kDa and a 22-kDa subunit between Val468 and Ala469 (PMID: 10672038). Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD).


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