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ACOX1 Antibody 30 Publications

Rabbit Polyclonal| Catalog number: 10957-1-AP

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Con: 45 μg/150 μl

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Tested Applications

Applications:
WB, IHC, IF, ELISA
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Images See all

ACOX1 Antibody WB mouse liver tissue 10957-1-AP

Various lysates were subjected to SDS PAGE followed by western blot with 10957-1-AP (ACOX1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours

ACOX1 Antibody IHC human liver cancer tissue 10957-1-AP

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10957-1-AP (ACOX1 antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

ACOX1 Antibody IHC human liver cancer tissue 10957-1-AP

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10957-1-AP (ACOX1 antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Species specificity:
human, mouse, rat, chicken
Positive WB detected in:
mouse liver tissue, mouse kidney tissue, rat liver tissue
Positive IHC detected in:
human liver cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:50-1:500
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
ACOX1 fusion protein Ag1405
Full name:
acyl-Coenzyme A oxidase 1, palmitoyl
Calculated molecular weight:
74 kDa
Observed molecular weight:
50 kDa
GenBank accession number:
BC010425
Gene ID (NCBI):
51
Gene symbol
ACOX1
Synonyms
ACOX, ACOX1, AOX, PALMCOX, Palmitoyl CoA oxidase, SCOX

Background

ACOX1(Peroxisomal acyl-coenzyme A oxidase 1) is the first and rate-limiting enzyme in the peroxisomal fatty acid beta-oxidation pathway and catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It belongs to the acyl-CoA oxidase family and also named as ACOX, AOX, SCOX. It has 3 isoforms produced by alternative splicing with the molecular mass of 70-74 kDa and can be cleaved post-translationally into a 50-kDa and a 22-kDa subunit between Val468 and Ala469 (PMID: 10672038). Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD).


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