alpha Adaptin Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 11401-1-AP

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Freight/Packing

Con: 45 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, human heart tissue, human spleen tissue, mouse spleen tissue

Positive IP detected in:
mouse skeletal muscle tissue

Positive IHC detected in:
human ovary tumor tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
adaptor-related protein complex 2, alpha 1 subunit

Calculated molecular weight:
977aa,108 kDa

Observed molecular weight:
108 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AP2A1

Synonyms
ADTAA, alpha Adaptin, Alpha adaptin A, Alpha1 adaptin, AP 2 complex subunit alpha 1, AP2 ALPHA, AP2A1, CLAPA1
Background

AP2A1 encodes adaptor protein complex 2 (AP-2) subunit alpha-1, which is a 100 kDa coated vesicle protein. Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a pivotal role in the cargo selection by recognizing the sorting signals within the cytoplasmic tail of integral membrane proteins. AP-2 is involved in clathrin-dependent endocytosis.


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