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androgen receptor Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 22089-1-AP

Featured Product KD/KO validated

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Con: 73 μg/150 μl

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Tested Applications

Applications:
WB, IHC, ELISA
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Images See all

androgen receptor Antibody WB MCF-7 cells 22089-1-AP

WB result of androgen receptor antibody (22089-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-androgen receptor transfected MCF-7 cells

androgen receptor Antibody WB MCF-7 cells 22089-1-AP

MCF7 cells were subjected to SDS PAGE followed by western blot with 22089-1-AP(androgen receptor antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours

androgen receptor Antibody IHC human prostate cancer tissue 22089-1-AP

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 22089-1-AP( androgen receptor antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Species specificity:
human, mouse, rat
Positive WB detected in:
MCF-7 cells, HepG2 cells, LNCaP cells, NIH/3T3 cells, mouse heart tissue
Positive IHC detected in:
human prostate cancer tissue, mouse ovary tissue
Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
androgen receptor fusion protein Ag17291
Full name:
androgen receptor
Calculated molecular weight:
914aa,99 kDa
Observed molecular weight:
75-80 kDa,100-110 kDa
GenBank accession number:
BC132975
Gene ID (NCBI):
367
Gene symbol
AR
Synonyms
AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM

Background

AR, also named as DHTR and NR3C4, belongs to the nuclear hormone receptor family and NR3 subfamily. AR is a ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. AR is activated, but not phosphorylated, by HIPK3. Defects in AR are the cause of androgen insensitivity syndrome (AIS), previously known as testicular feminization syndrome (TFM), which is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) which also known as Kennedy disease. Defects in AR may play a role in metastatic prostate cancer. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) which also known as Reifenstein syndrome. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human AR. AR exists various isoforms with MV 110 kDa and 75-80 kDa. (PMID: 19244107 )


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