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Co-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas.
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Serine/threonine kinase 6(STK6),also named as STK15 and AIK, belongs to the Ser/Thr protein kinase family. This protein may play a role in cell cycle regulation during anaphase and/or telophase by being involved in microtubule formation and/or stabilization. Some recent evidence revealed that STK6 may also be implicated in tumor development and progression. STK6 is expressed highly in testis and various proliferating cells, migrating as a 46 kDa protein in SDS PAGE.Nuclear staining for AURKA is weak or nonexistent in normal tissue but strong in tumor tissue(PMID:19107951).