AXIN2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20540-1-AP

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Freight/Packing

Con: 70 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, BxPC-3 cells, MDA-MB-453s cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
axin 2

Calculated molecular weight:
843aa,94 kDa

Observed molecular weight:
93-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AXIN2

Synonyms
AXIL, axin 2, Axin like protein, AXIN2, Axis inhibition protein 2, Conductin, DKFZp781B0869
Background

Axis inhibition protein2 (AXIN2), also known as Coductin or Axil, is a multidoman scaffold protein that negatively regulate Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has a number of phosphorylation sites, and also can undergo poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2. Poly(ADP-ribosy)lated AXIN2 then get unbiquitinated by RNF146 and leads to its degradation and subsequent activation of Wnt signaling. AXIN2 is localized in the cytoplasm and its mutaion is involved in colorectal cancer. Catalgo#20540-1-AP is a rabbit polyclonal antibdy raised against a 34 amino acid N-terminal of human AXIN2.


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